Development of a Self-Emulsifying Adjuvant for Use in Swine Vaccines
نویسندگان
چکیده
Emulsion-based adjuvants are commonly used in animal vaccine formulations for several reasons including affordability, stability, and efficacy inducing disease-protecting immune responses. Here we report a novel, cost-effective, stable, self-emulsifying adjuvant (SEA1) that is prepared by simple low shear process or low-energy mixing without the use of expensive complex proprietary equipment. Characterization SEA1 showed good stability at different temperatures (4°C, 20°C, 37°C) after one month storage. Minimal changes droplet size distribution, polydispersity index, Zeta potential pH 1-month-old preparations were observed when compared with fresh preparation. emulsion-based experimental effectively stimulated humoral immunoglobulin (IgG) responses mice swine comparable to commercially available Montanide ISA 201 206.
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ژورنال
عنوان ژورنال: Kansas Agricultural Experiment Station Research Reports
سال: 2022
ISSN: ['2378-5977']
DOI: https://doi.org/10.4148/2378-5977.8398